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Systemic Delivery of Nanoformulations of Anti-cancer Drugs with Therapeutic Potency in Animal Models of Cancer

[ Vol. 12 , Issue. 3 ]

Author(s):

Md. Emranul Karim, Rozita Rosli and Ezharul H. Chowdhury   Pages 204 - 220 ( 17 )

Abstract:


Despite being widely used for cancer treatment, conventional chemotherapeutic regimens based on anti-cancer drugs possess significant drawbacks in discriminating between normal and cancer cells, leading to detrimental effects on healthy tissues. The development of nano-formulations encapsulating the chemotherapy drugs is highly expected to improve the anti-cancer activities with favorable pharmacokinetic profile and consequentially minimized side-effects. Several organic and inorganic nanoparticles have received tremendous attention as carriers of various anticancer drugs in pre-clinical and clinical settings. In this review, we discuss on the progress of formulating and investigating various nano-formulationsin treating different cancers, with an emphasis on in vivo studies utilizing the nanoparticles for carrying small molecular weight anti-cancer drugs and focusing on the biocompatibility, targeting capability, cellular uptake, and the tumor regression efficacy of those nano-formulations.

Keywords:

Cancer, multi-functional nanoparticle, anti-cancer drug, active targeting, passive targeting, EPR effect, controlled release.

Affiliation:

Jeffrey Cheah School of Medicine and Health Sciences, Faculty of Medicine, Nursing and Health Sciences, MONASH University

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