Article Details


DMBA- Induced Breast Cancer: A Hormonal Camouflage

[ Vol. 12 , Issue. 4 ]

Author(s):

Anita K. Bakrania, Bhavesh C. Variya and Snehal S. Patel   Pages 273 - 280 ( 8 )

Abstract:


Background: Breast cancer is one of the high prevalence cancers worldwide affecting women based on various factors. Hormonal changes are amongst the factors involved in the development of breast cancer. The basic hormones involved include estrogen and progesterone with human epidermal receptor-2 (HER2) which could be either over expressed or not at all expressed. Therefore, studies were conducted on the DMBA induced breast cancer model.

Methods: As per literature review, there has been complete befuddlement on the hormonal crisis of the DMBA induced model hence we performed the immunohistochemistry studies of estrogen, progesterone and human epidermal receptor-2 in order to prove the presence or absence of the major hormones involved in progression of breast cancer. Preceding morphological tumor detection, it was further confirmed with hematoxylineosin stained sections.

Results: These data initially detected the probable presence of mucin in the hematoxylin- eosin stain hence we performed specific mucin stain using Meyer’s mucincarmine concluding mucinous carcinoma. Thereafter, we obtained negative estrogen and HER2, with positive progesterone in the immunohistochemistry studies.

Conclusion: Conclusively, DMBA induced breast cancer is a suitable model for mucinous carcinoma in estrogen and human epidermal receptor-2 negative and progesterone positive breast cancer.

Keywords:

Breast cancer, DMBA, Estrogen, Progesterone, HER-2, DNA, carcinomace.

Affiliation:

Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, 382 481, Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, 382 481, Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, 382 481

Graphical Abstract:



Read Full-Text article