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Therapeutic Peptide Mimetics Looking for a Turn to Block Aberrant Players of Malignancy

[ Vol. 13 , Issue. 2 ]

Author(s):

Pritish Nilendu, Sayantani Roychoudhary, Karishma Deshpande and Nilesh K. Sharma*   Pages 89 - 106 ( 18 )

Abstract:


Background: Currently, existing regimens of genotoxic drugs have been suggested to be complemented with molecular inhibitors as combinatorial and cocktail approaches in malignancy.

Methods: In the last decade, attempts have been reported to test several new class of anticancer drug such as miRNA mimetics, RNA enzymes, small molecular inhibitors, DNA repair protein inhibitors and peptide mimetics.

Results: With the advent of rapidly growing genomic, epigenomic and proteomic data, design and application of peptide mimetics appear to thrive and sustain for an impactful cancer therapy. However, certain bottlenecks are envitable such as delivery of peptide mimetics drug in clinical settings, reducing the side effects, immune responses and pharmacokinetic properties.

Conclusion: This review discusses emerging issues and potential avenues related to the scope and limitations of peptide mimetics in cancer treatment.

Keywords:

Cellular growth, cancer, proteomics, protein, regulation, signaling pathway, targeted therapy.

Affiliation:

Cancer and Translational Research Lab, Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, Cancer and Translational Research Lab, Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, Cancer and Translational Research Lab, Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, Cancer and Translational Research Lab, Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra

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