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Role of Stereotactic Radiosurgery in the Management of Brain and Spine Metastases

[ Vol. 14 , Issue. 1 ]

Author(s):

Jacob A. Miller, Ehsan H. Balagamwala and Samuel T. Chao*   Pages 55 - 67 ( 13 )

Abstract:


Introduction: The role of stereotactic radiosurgery is increasing in the management of brain and spine metastases. We review the data supporting its use.

Methods: We used data to compile recommendations for indications, prescription dose and dose constraints, treatment outcomes, and toxicities.

Results: Stereotactic radiosurgery is demonstrated to be effective and safe in the management of brain and spine metastases, both upfront and for recurrence. Toxicities, particularly radiation necrosis and myelopathy, can be morbid and need to be followed for.

Conclusion: While the data support its use, there needs to be continued research with improved technology, on the use of radiosurgery for larger brain metastases, and on the toxicities of radiosurgery and its management.

Keywords:

Stereotactic radiosurgery, stereotactic body radiation therapy, brain metastases, spine metastases, Central Nervous System (CNS), Bone.

Affiliation:

Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, 44195, Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, 44195, Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, 44195

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