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Development, Characterization and Anticancer Evaluation of Silver Nanoparticles from Dalbergia sissoo Leaf Extracts

[ Vol. 16 , Issue. 2 ]

Author(s):

Aakash Deep*, Mitali Verma, Rakesh K. Marwaha, Arun K. Sharma and Beena Kumari   Pages 145 - 151 ( 7 )

Abstract:


Aim: The objective behind this present work is the development and characterization of silver nanoparticles from Dalbergia sissoo leaf extracts and the analysis of anticancer activity.

Methods: Silver nanoparticles were prepared by using the aqueous solution of Dalbergia sisoo leaf extract and silver nitrate. The formation of nanoparticles was determined by the color change during the preparation of plant extract to metal ion in a fixed ratio. The prepared nanoparticles were then characterized by TEM, FTIR, DLS, XRD, and SEM. Silver nanoparticles were also evaluated for anticancer activity.

Results: Synthesized silver nanoparticles were having good anticancer activity against MCF 7 cancer cell line as compared to the standard drug Doxorubicin.

Conclusion: The particle size of nanoparticles was found to lie in the range of 10 to 50 nm.

Keywords:

Nanotechnology, nanoparticles, green synthesis, Dalbergia sisoo leaf extract, AgNPs, AuNPs.

Affiliation:

Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhwani 127021, Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhwani 127021, Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, Haryana, Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Gurugram, Haryana 122051, Department of Pharmaceutical Sciences, Indira Gandhi University, Meerpur, Rewari

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