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MiR-492 as an Important Biomarker for Early Diagnosis and Targeted Treatment in Different Cancers

[ Vol. 16 , Issue. 4 ]

Author(s):

Eskandar Taghizadeh, Forough Taheri, Daryoush Rostami, Pedram G. Renani , Gordon A. Ferns, Alireza Pasdar* and Majid G. Mobarhan*   Pages 269 - 275 ( 7 )

Abstract:


Recent studies have led to a more detailed understanding of the roles played by microRNAs in health and disease, and their potential use as biomarkers in physiological and pathophysiological processes involving cancer initiation and progression. MiR-492 is encoded by a pseudogene, has a key role in some human cancer cells and its overexpression in tissues, and it has been proposed that it can be used as a good biomarker for management and early diagnosis of some cancers including breast cancer, colorectal and ovarian cancer, hepatocellular cancer, retinoblastoma and pancreatic cancer. The aim of this review was to summarize the data of MiR-492 for early diagnosis and treatment of some types of related cancers.

Keywords:

MiR-492, breast cancer, microRNAs, colorectal cancer, RNA-silencing, biomarker.

Affiliation:

Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Sharekord Branch, Islamic Azad University, Sharekord, Department of School Allied, Zabol University of Medical Sciences, Zabol, Sharekord Branch, Islamic Azad University, Sharekord, Department of Medical Education, Brighton and Sussex Medical School, Perso Falmer, Brighton, Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Metabolic Syndrome Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad

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