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YB-1 Activities in Oncogenesis: Transcription and Translation

[ Vol. 2 , Issue. 1 ]

Author(s):

Andreas G. Bader   Pages 31 - 39 ( 9 )

Abstract:


The Y box-binding protein 1 (YB-1) is a multifunctional DNA/RNA-binding protein regulating transcriptional and translational processes. Emerging evidence suggests a role for YB-1 in malignant human disease. Protein expression levels of YB-1 are increased in numerous human cancers, and nuclear YB-1 correlates with poor prognosis of tumor patients. However, YB-1 has also anti-oncogenic activities and interferes with phosphoinositide 3-kinase dependent cellular transformation. The anti-oncogenic activity correlates with cytoplasmic localization and with inhibition of protein synthesis. This review seeks to highlight the transcriptional and translational functions of YB-1 and its role in oncogenesis.

Keywords:

Y box, DbpB, p50, NSEP-1, EF-IA, mRNP

Affiliation:

The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, BCC 239, La Jolla, CA 92037, USA.



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